Role of conformational dynamics in sequence-specific autoantibody•ssDNA recognition
نویسندگان
چکیده
منابع مشابه
Role of conformational dynamics in sequence-specific autoantibody*ssDNA recognition.
11F8 is a sequence-specific monoclonal anti-ssDNA autoantibody isolated from a lupus prone mouse that forms pathogenic complexes with ssDNA, resulting in kidney damage. Prior studies show that specificity is mediated by a somatic mutation from serine at (31)V(H) to arginine. Reversion back to serine in 11F8 resulted in >30-fold decrease in affinity and altered thermodynamic and kinetic paramete...
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15 صفحه اولConformational modulation of sequence recognition in synthetic macromolecules.
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ژورنال
عنوان ژورنال: Biopolymers
سال: 2007
ISSN: 0006-3525,1097-0282
DOI: 10.1002/bip.20692